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申请/专利权人：山西医科大学

摘要：本发明涉及一种基于体液特异性mRNAcSNP解析混合斑中体液供者的方法，针对体液特异性mRNA分子cSNP基因座，构建了多重PCR靶向捕获测序的cSNP分型系统，包含有6种体液组织的202个cSNP。本发明通过评估该系统cSNP的个体识别能力，体液特异性以及对由2～6种不同成分组成的混合斑的解析能力，构建了解析混合斑中体液供者的方法，特异性基因分型结果均与供者原始分型一致。

主权项：1.基于体液特异性mRNAcSNP解析混合斑中体液供者的方法，是构建一个多重PCR靶向捕获测序的cSNP分型系统，在该系统中包含血液、月经血、唾液、精液、皮肤和阴道分泌液6种体液组织的202个cSNP，其中包括：来源于血液的46个cSNP：rs1052231、rs1052230、rs3831958、rs1071849、rs17645、rs1889490、rs885822、rs885821、rs619250、rs2298831、rs1793174、rs17121881、rs3753059、rs3753058、rs8705、rs1128334、rs4937333、rs2230004、rs10844140、rs2058429、rs2058428、rs201801226、rs2058427、rs2058426、rs3214342、rs1135816、rs45628133、rs229592、rs184528、rs1741488、rs1741487、rs1626923、rs17245552、rs229587、rs229586、rs3817656、rs384138、rs17608、rs10485828、rs7658293、rs7687256、rs7682260、rs750625、rs504574、rs2304873、rs2304871；来源于月经血的16个cSNP：rs14983、rs10502001、rs470168、rs12532、rs1052981、rs1052974、rs1052969、rs1802074、rs1802073、rs1132553、rs1132552、rs3824220、rs1062998、rs2936、rs1438453、rs1438452；来源于唾液的17个cSNP：rs76504934、rs61930108、rs371841290、rs111543911、rs113897264、rs10845341、rs1849937、rs1136515、rs2988、rs3733493、rs2306948、rs3733492、rs3733491、rs3832306、rs3822163、rs3822162、rs5859232；来源于精液的31个cSNP：rs1803283、rs1136165、rs1042079、rs737008、rs1054072、rs11573、rs1135766、rs1058205、rs6998、rs198972、rs198977、rs198978、rs1139132、rs1654556、rs12150961、rs2301366、rs5763269、rs165923、rs165602、rs165625、rs1061373、rs2271087、rs1995640、rs1995641、rs3749195、rs9876921、rs1007、rs4872176、rs34783892、rs4872177、rs1567669；来源于皮肤的46个cSNP：rs773866497、rs76514540、rs138997916、rs12758283、rs12754184、rs12758293、rs12738471、rs2282302、rs2282303、rs3737859、rs873775、rs944682、rs3814350、rs3814351、rs41268492、rs4845487、rs1048534、rs2006940、rs3132555、rs3095298、rs1042149、rs3094220、rs9263641、rs1042147、rs1042146、rs3094219、rs1042145、rs1042141、rs3094218、rs3094217、rs1042134、rs3095297、rs56899166、rs3130981、rs3094216、rs3130982、rs3132554、rs1042127、rs1042126、rs1062470、rs4713436、rs3094215、rs707913、rs3130983、rs3132553、rs3132552；以及来源于阴道分泌液的46个cSNP：rs1020694、rs1020693、rs9959343、rs35845041、rs12986368、rs61147939、rs112313064、rs9807877、rs376263993、rs145605189、rs2246901、rs2246980、rs2550240、rs2293232、rs2259102、rs2259292、rs2688513、rs200129320、rs199896027、rs62282480、rs2911273、rs2911272、rs1106502、rs1104760、rs882605、rs6892205、rs34482796、rs2303063、rs2303064、rs2303065、rs2303067、rs880687、rs2303071、rs17704908、rs33920397、rs2303070、rs4349706、rs3088193、rs2077647、rs1801132、rs2228480、rs3798577、rs3798758、rs1062577、rs2532925、rs4713402。

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百度查询： 山西医科大学 基于体液特异性mRNA cSNP解析混合斑中体液供者的方法